NanoMedica scientists are developing new ways to rapidly select novel drug candidates from vast molecular libraries containing billions of DNA-encoded members with single-molecule resolution. We do so by leveraging the power of Next-Generation Sequencing to quantify the affinity of every target-binding molecule in the library.
Our proprietary methodology for decoding DNA-encoded libraries leverages ultrasensitive single-molecule selection methods coinvented by a highly collaborative team of academic and industrial physicists, chemists and biologists working under one roof. We have unique relationships with leading institutions that grant us access to best-in-class facilities, equipment and expertise through a success-driven virtual team approach. Our goal is to help you get the most from your DNA-encoded libraries through single-molecule selection of the highest affinity binders.
We adapt our discovery methods to your purposes by selecting target-binding drug candidates from your DNA-encoded libraries. We interrogate libraries using a patented decoding approach designed to reduce both false positives and false negatives via in situ target binding assays in individual wells of Next Generation Sequencing arrays. All identified compounds and corresponding IP remain entirely yours. Our goal is simply to provide you the greatest possible visibility into the value of your libraries by determining the target-binding affinity of each library member.
We provide you with quantitative information on the binding affinity, association and dissociation rates of target-binding molecules in DNA-encoded libraries without the need to first perform de novo compound synthesis. What differs about our approach is that we directly measure binding affinities of encoded molecules rather than relying on indirect estimates like PCR copy number. The result is that you get a quantitative affinity measure for every target-binding molecule in your library without troublesome false positives, false negatives or amplification artifacts.
NanoMedica LLC, Winston-Salem, NC 27101
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